At graduation from the University of Chicago Pritzker School of Medicine, Breyer was elected to the Alpha Omega Alpha honor society,   achieved campus wide honors and was given the John Van Prohaska Award for outstanding potential in teaching, research, and clinical medicine. After residency at UCSF, Breyer completed a fellowship in complex male genitourinary reconstruction and trauma surgery under the direction, of Jack W. McAninch, MD.  Breyer joined the faculty in 2011. In 2014, he was named Chief of Urology, Zuckerberg San Francisco General Hospital and Trauma Center, where is passionate about leading the Department’s lean quality and safety initiatives. In 2015, Dr. Breyer became Residency Program Associate Director. In 2017, Breyer became a Vice-Chair of the Department. Breyer’s research team focuses on genitourinary reconstruction particularly urethral stricture disease, trauma, sexual medicine, and health disparities. Their work has been supported by the National Institutes of Health, foundation and intramural grants, and grateful patients. Breyer’s lab has published over 300 peer-reviewed papers and scholarly works. In 2023, Dr. Breyer became the Chair of the Department.